The action of testosterone can be in ways both beneficial and
detrimental to the body. On the plus side, this hormone has a direct impact on the growth
of muscle tissues, the production of red blood cells and overall well being of the organism.
But it may also negatively effect the production of skin oils, growth of body, facial and
scalp hair, and the level of both "good" and "bad" cholesterol in the body [among other
things]. In fact, men have a shorter average life span than women, which is believed to be
largely due to the cardiovascular defects that this hormone may help bring about.
Testosterone will also naturally convert to estrogen in the male body, a hormone with
its own unique set of effects. As we have discussed earlier, raising the level of estrogen
in men can increase the tendency to notice water retention, fat accumulation, and will often
cause the development of female tissues in the breast [gynecomastia]. Clearly we see that
most of the "bad" side effects from steroids are simply those actions of testosterone that
we are not looking for when taking a steroid. Raising the level of testosterone in the
body will simply enhance both its good and bad properties, but for the most part we are
not having "toxic" reactions to these drugs. A notable exception to this is the
possibility of liver damage, which is a worry isolated to the use of c17-alpha alkylated
oral steroids. Unless the athlete is taking anabolic/androgenic steroids abusively for a
very long duration, side effects rarely amount to little more than a nuisance. One could
actually make a case that periodic steroid use might even be a healthy practice.
Clearly a person physical shape can relate closely to one overall health and well being.
Provided some common sense is paid to health checkups, drug choice, dosage and off-time,
how can we say for certain that the user is worse off for doing so? This position is of
course very difficult to publicly justify with steroid use being so deeply stigmatized.
Since this can be a very lengthy discussion, we will save the full health, moral and legal
arguments for another time. For now I would like to run down the list of popularly discussed
side effects, and include any current treatment/avoidance advice where possible.
Rampant acne is one of the more obvious indicators of steroid use. As you know, teenage
boys generally endure periods of irritating acne as their testosterone levels begin to
peak, but this generally subsides with age. But when taking anabolic/androgenic steroids,
an adult will commonly be confronted with this same problem. This is because the sebaceous
glands, which secrete oils in the skin, are stimulated by androgens. Increasing the level
of such hormones in the skin may therefore enhance the output of oils, often causing acne
to develop on the back, shoulders, and face. The use of strongly androgenic steroids in
particular can be very troublesome, in some instances resulting in very unsightly blemishes
all over the skin. To treat acne, the athlete has a number of options. The most obvious
of course is to be very diligent with washing and topical treatments, so as to remove much
of the dirt and oil before the pores become clogged. If this proves insufficient, the
prescription acne drug Accutaine might be a good option. This is a very effective
medication that acts on the sebaceous glands, reducing the level of oil secreted.
The athlete could also take the ancillary drug Proscar/Propecia [finasteride] during
steroid treatment, which reduces the conversion of testosterone into DHT, lowering the
tendency for androgenic side effects with this hormone. It is of note however that this
drug is more effective at warding off hair loss than acne, as it more specifically effects
DHT conversion in the prostate and hair follicles. It is also important to note that
testosterone is the only steroid that really converts to dihydrotestosterone, and only a
few others actually convert to more potent steroids via the 5a-reductase enzyme at all.
Many steroids are also potent androgens in their own right, such as Anadrol 50 and
Dianabol for example. As such they can exert strong androgenic activity in target tissues
without 5a-reduction to a more potent compound, which makes Propecia useless. Of course
one can also simply take those steroids [anabolics] that are less androgenic.
For sensitive individuals attempting to build mass, nandrolone would therefore be a much
better option than testosterone.
Aggressive behaviour can be one of the scarier sides to steroid use. Men are typically
more aggressive than women because of testosterone, and likewise the use of steroids
[especially androgens] can increase a person aggressive tendencies. In some instances
this can be a benefit, helping the athlete hit the weights more intensely or perform
better in a competition. Many professional power lifters and bodybuilders take a
particular liking to this effect. But on the other hand there is nothing more unsettling
than a grown man, bloated with muscle mass, who cannot control his temper. A steroid user
who displays an uncontrollable rage is clearly a danger to himself and others. If an
athlete is finding himself getting agitated at minor things during a steroid cycle,
he should certainly find a means to keep this from getting out of hand. Remembering to
take a couple of deep breaths at such times can Be very helpful. If such attempts prove
to be ineffective, the offending steroids should be discontinued. The bottom line is that
if you lack the maturity and self control to keep your anger in check, you should not be
Anaphylactic shock is an allergic reaction to the presence of a foreign protein in the body.
It most commonly occurs when an individual has an allergy to things like a specific
medication [such as penicillin], insect bites, industrial/household chemicals, foods
[commonly nuts, shellfish, fruits] and food additives/preservatives [particularly sulfur].
With this sometimes-fatal disorder the smooth muscles are stimulated to contract, which
may restrict a person breathing. Symptoms include wheezing, swelling, rash or hives, fever,
a notable drop in blood pressure, dizziness, unconsciousness, convulsions or death.
This reaction is not really seen with hormonal products like anabolic/androgenic steroids,
but this may change with the rampant manufacture of counterfeit pharmaceuticals.
Being that there are no quality controls for black market producers, toxins might
indeed find their way into some preparations [particularly injectable compounds].
My only advice would be to make every attempt to use only legitimately produced drug
products, preferably of First World origin. When anaphylactic shock occurs, it is most
commonly treated with an injection of epinephrine. Individuals very sensitive to certain
insect bites are familiar with this procedure, many of who keep an allergy kit
[for the self administration of epinephrine] close at hand.
Anabolic/androgenic steroids can have a very pronounced impact on the development of an
unborn fetus. Adrenal Genital Syndrome in particular is a very disturbing occurrence,
in which a female fetus can develop male-like reproductive organs. Women who are, or
plan to become pregnant soon, should never consider the use of anabolic steroids.
It would also be the best advice to stay away from these drugs completely for a number
of months prior to attempting the conception of a child, so as to ensure the mother has
a normal hormonal chemistry. Although anabolic/androgenic steroids can reduce sperm count
and male fertility, they are not linked to birth defects what taken by someone fathering
Blood Clotting Changes
The use of anabolic/androgenic steroids is shown to increase prothrombin time, or the
duration it will take for a blood clot to form. This basically means that while an
individual is taking steroids, he/she may notice that it takes slightly longer than usual
for a small cut or nosebleed to stop seeping blood. During the course of a normal day
this is hardly cause for alarm, but it can lead to more serious trouble if a severe
accident occurred, or an unexpected surgery was needed. Realistically the changes in
clotting time are not extremely dramatic, so athletes are usually only concerned with
this side effect if planning for a surgery. The clotting changes brought about by
anabolic steroids are amplified with the use of medications like Aspirin, Tylenol and
especially anticoagulants, so your doctor should be informed of their use [steroids]
if undergoing any notable treatment with these types of drugs.
Although it is a popular belief that steroids can give you cancer, this is actually a
very rare phenomenon. Since anabolic/androgenic steroids are synthetic version of a
natural hormone that your body can metabolize quite easily, they usually place a very low
level of stress on the organs. In fact, many steroidal compounds are safe to administer
to individuals with a diagnosed liver condition, with little adverse effect. The only
real exception to this is with the use of C17 alpha alkylated compounds, which due to
their chemical alteration are somewhat liver toxic. In a small number of cases
[primarily with Anadrol 50] this toxicity has lead to severe liver damage and
subsequently cancer. But we are speaking of a statistically insignificant number in the
face millions of athletes who use steroids. These cases also tended to be very ill
patients, not athletes, who were using extremely large dosages for prolonged periods of
time. Steroid opponents will sometimes point out the additional possibility of developing
Wilms Tumor from steroid abuse, which is a very serious form of kidney cancer.
Such cases are so rare however, that no direct link between anabolic/androgenic steroid
use and this disease has been conclusively established. Provided the athlete is not
overly abusing methylated oral substances, and is visiting a doctor during heavier cycles,
cancer should not be much of a concern.
As mentioned earlier, the use of anabolic/androgenic steroids may have an impact on the
level of LDL [low density lipoprotein], HDL [high density lipoprotein] and total
cholesterol values. As you probably know, HDL is considered the "good" cholesterol since
it can act to remove cholesterol deposits from the arteries. LDL has the opposite effect,
aiding in the buildup of cholesterol on the artery walls. The general pattern seen with
steroid use is a lowering of HDL concentrations, while total and LDL cholesterol numbers
increase. The ratio of HDL to LDL values is usually more important than one total
cholesterol count, as these two substances seem to balance each other in the body.
If these changes are exacerbated by the long-term use of steroidal compounds, it can
clearly be detrimental to the cardiovascular system. This may be additionally heightened
by a rise in blood pressure, which is common with the use of strongly aromatizable
It is also important to note that due to their structure and form of administration,
most 17 alpha alkylated oral steroids have a much stronger negative impact on these
levels compared to injectable steroids. Using a milder drug like Winstrol [stanozolol],
in hopes HDL level changes will also be mild, may therefore not turn out to be the best
option. One study comparing the effect of a weekly injection of 200mg testosterone
enanthate vs. only a 6mg daily oral dose of Winstrol makes this very clear.
After only six weeks, stanozolol was shown to reduce HDL and HDL-2 [good] cholesterol
by an average of 33% and 71% respectively. The HDL reduction [HDL-3 subfraction]
with the testosterone group was only an average of 9%. LDL [bad] cholesterol also rose
29% with stanozolol, while it actually dropped 16% with the use of testosterone.
Those concerned with cholesterol changes during steroid use may likewise wish to avoid
oral steroids, and opt for the use of injectable compounds exclusively.
We also must note that estrogens generally have a favorable impact on cholesterol
profiles. Estrogen replacement therapy in postmenopausal women for example is regularly
linked to a rise in HDL cholesterol and a reduction in LDL values. Likewise the
aromatization of testosterone to estradiol may be beneficial in preventing a more
dramatic change in serum cholesterol due to the presence of the hormone. A
recent study investigated just this question by comparing the effects of
testosterone alone [280 mg testosterone enanthate weekly], vs. the same dose combined
with an aromatase inhibitor [250mg testolactone 4 times daily] Methyltestosterone
was also tested in third group, at a dose of 20mg daily. The results were quite
enlightening. The group using only testosterone enanthate showed no significant
decrease in HDL cholesterol values over the course of the 12 week study. After only
four weeks the group using testosterone plus an aromatase inhibitor displayed a
reduction of 25% on average. The methyltestosterone group noted an HDL reduction of 35%
by this point, and also noted an unfavourable rise in LDL cholesterol. This clearly
should make us think a little more closely about estrogen maintenance during steroid
therapy. Aside from deciding whether or not it is actually necessary in any given
circumstance, drug choice may also be an important consideration. For example, the
estrogen receptor antagonist Nolvadex does not seem to exhibit ant estrogenic effects
on cholesterol values, and in fact often raises HDL levels. Using this to combat the
side effects of estrogen instead of an aromatase inhibitor such as Arimidex or
Cytadren may therefore be a good idea, particularly for those who are using steroids
for longer periods of time. Since heart disease is one of the top killers worldwide,
steroid using athletes [particularly older individuals] should not ignore these risks.
If nothing else it is a very good idea to have your blood pressure and cholesterol
values measured during each heavy cycle, being sure to discontinue the drugs should a
problem become evident. It is also advisable to limit the intake of foods high in
saturated fats and cholesterol, which should help minimize the impact of steroid
treatment. Since blood pressure and cholesterol levels will usually revert back to
their pre-treated norms soon after steroids are withdrawn, long-term damage is not a
Steroid use will obviously have an impact on hormone levels in the body, which in turn may
result in a change in ones general disposition or mood. On the one hand we might see
very aggressive behaviour, but the other extreme of depression also exists. Depression
usually occurs at times when an individual androgen/estrogen levels are significantly
off balance. This is most common with male bodybuilders, at times when anabolic/androgenic
steroids are discontinued. During this period estrogen levels may be markedly elevated
[from the aromatization of steroids], which is often coupled with a deeply suppressed
endogenous testosterone level. Once the steroids are no longer present in the body, the
athlete may suffer with a low androgen level until the body catches up. Depression may
also occur during the course of a steroid cycle, particularly with the sole use of
anabolics. Although these compounds are mild in comparison to androgens, many can still
suppress the endogenous Production of testosterone. If the testosterone level drops
significantly during treatment, the administered anabolics may not provide enough of
an androgen level to compensate, and a marked loss of motivation and sense of well-being
may result. The best advice when looking to avoid cycle or post-cycle depression is to
closely monitor drug intake and withdrawal. The use of a small weekly testosterone dose
might prove very effective if added to a mild dieting/anabolic cycle, warding off feelings
of boredom and apathy to training. And of course a strong steroid cycle should always
be discontinued with the proper use of ancillary drugs [Nolvadex, Arimidex, HCG, Clomid etc.].
Although tapering schedules are very common, they are not an effective way to restore
endogenous testosterone levels.
Gynecomastia is the medical term for the development of female breast tissues in the male
body. This occurs when the male is presented with unusually high level of estrogen,
particularly with the use of strong aromatizing androgens such as testosterone and
Dianabol. The excess estrogen can act upon receptors in the breast and stimulate the
growth of mammary tissues. If left unchecked this can lead to an actual obvious and
unsightly tissue growth under the nipple area, in many cases taking on a very feminine
appearance. To fight this side effect during steroid therapy, many find it necessary the
use some form of estrogen maintenance medication. This includes an estrogen antagonist
such as Clomid or Nolvadex, which blocks estrogen from attaching to and activating
receptors in the breast and other tissues, or an aromatase inhibitor such as Proviron,
Cytadren or Arimidex, which blocks the enzyme responsible for the conversion of
androgens to estrogens. Arimidex is currently the most effective option, but is
also the most costly.
It is worth noting however, that many believe a slightly elevated estrogen level may help
the athlete achieve a more pronounced muscle mass gain during a cycle
[see: Estrogen Aromatization]. With this in mind many athletes decide to use
antiestrogens only when it is necessary to block gynecomastia. It is of course still a
good idea to always keep an antiestrogen on-hand when administering an aromatizable steroid,
so that it is readily accessible should trouble become evident. Puffiness or swelling
under the nipple is one of the first signs of pending gynecomastia, which is often
accompanied by pain or soreness in this region [an effect termed gynecodynea].
This is a clear indicator that some type of antiestrogen is needed. If the swelling
progresses into small, marble like lumps, action absolutely must be taken immediately
to treat it. Otherwise if the steroids are continued at this point without ancillary
drug use, the user will likely be stuck with unsightly tissue growth that can only be
removed with a surgical procedure.
It is also important to mention that progestins seem to augment the stimulatory effect of
estrogens on mammary tissue growth. There appears to be a strong synergy between these
two hormones here, such that gynecomastia might even be able to occur with the help of
progestins, without excessive estrogen levels being necessary. Since many anabolic
steroids, particularly those derived from nandrolone, are known to have progestational
activity, we must not be lulled into a false sense of security. Even a low estrogen
producer like Deca Durabolin can potentially cause gyno in certain cases, again fostering the
need to keep anti-estrogens close at hand if you are very sensitive to this side effect.
The use of highly androgenic steroids can negatively impact the growth of scalp hair.
In fact the most common form of male pattern hair loss is directly linked to the level
of androgens in such tissues, most specifically the stronger DHT metabolite of
testosterone. The technical term for this type of hair loss is androgenetic alopecia,
which refers to the interplay of both the male androgenic hormones and a genetic
predisposition in bringing about this condition. Those who suffer from this disorder
are shown to posses finer hair follicles and higher levels of DHT in comparison to a
normal, hairy scalp. But since there is a genetic factor involved, many individuals
will not ever see signs of this side-effect, even with very heavy steroid use.
Clearly those individuals who are suffering from [or have a familial predisposition for]
this type of hair loss should be very cautious when using the stronger drugs like
testosterone, Anadrol 50, Halotestin and Dianabol.
In many instances the renewal of lost hair can be very difficult, so avoiding this side
effect before it occurs is the best advice. For those who need to worry, the decision
should probably be made to either stick with the milder substances
[Deca-Durabolin most favoured], or to use the ancillary drug Propecia/Proscar
[finasteride] when taking testosterone, methyltestosterone or Halotestin. Propecia
is a very effective hair loss medication, which inhibits the 5-alpha reductase enzyme
specifically in the hair follicles and prostate. This item offers us little benefit with
drugs that are highly androgenic without 5alpha reduction however, the most notable
offenders being Anadrol 50 and Dianabol. We must also remember also that all
anabolic/androgenic steroids activate the androgen receptor, and can likewise all
promote hair loss given the right dosage and conditions.
Athletes sometimes report an increased frequency of headaches when using
anabolic/androgenic steroids. This seems to be most common during heavier bulking cycles,
when an individual is utilizing strongly estrogenic compounds. One should not simply
take an aspirin and ignore this problem, as it is may indicate a more troubling side
effect of steroid use, high blood pressure. Since high blood pressure invites with it
a number of unwanted health risks, monitoring it on a regular schedule is important
during heavy steroid use, especially if the individual is experiencing headaches.
Some athletes choose to lower their blood pressure in such cases with a prescription
medication like Catapres, but most find this an appropriate time to discontinue
steroid use. Milder anabolics, which generally display little or no ability to convert
to estrogen, are also more acceptable options for individuals sensitive to blood
pressure increases. Less seriously, many headaches are due to simple strain on the neck
and scalp muscles. The athlete may be lifting with much more intensity during a steroid
cycle, and as a result may place added strain on these muscles. In this case a short
break from training, and general rest, will often take care of the problem.
Of course if anyone is experiencing a very serious or persistent headache, a
visit to the doctor may be in order.
High Blood Pressure/Hypertension
Athletes using anabolic/androgenic steroids will commonly notice a rise in blood
pressure during treatment. High blood pressure is most often associated with the use
of steroids that have a high tendency for estrogen conversion, such as testosterone and
Dianabol. As estrogen builds in the body, the level of water and salt retention will
typically elevate (which will increase blood pressure). This may be further amplified
by the added stress of intense weight training and rapid weight gain. Since hypertension
[high blood pressure] can place a great deal of stress on the body, this side effect
should not be ignored. If it is left untreated, high blood pressure can increase the
likelihood for heart disease, stroke or kidney failure. Warning signs that one may
be suffering from hypertension include an increased tendency to develop headaches,
insomnia or breathing difficulties. In many instances these symptoms do not become
evident until BP is seriously elevated, so a lack of these signs is no guarantee that
the user is safe. Obtaining your blood pressure reading is a very quick and easy
procedure [either at a doctors office, pharmacy or home]; steroid-using athletes
should certainly be monitoring BP values during stronger cycles so as to avoid potential
If an individual blood pressure values are becoming notably elevated, some action
should/must be taken to control it. The most obvious is to avoid the continued use
of the offending steroids, or at least to substitute them with milder, non-aromatizing
compounds. It is also of note that although aromatizing steroids are typically involved,
nonaromatizing androgens like Halotestin or trenbolone are occasionally also been
linked to high blood pressure, so these are perhaps not the ideal alternatives in
such a situation. The athlete also has the option of seeking the benefit of high blood
pressure medications such as diuretics, which can dramatically lower water and salt
retention. Catapres [clonidine HCL] is also a popular medication among athletes,
because in addition to its blood pressure lowering properties it has also been documented
to raise the body output of growth hormone.
Immune System Changes
The use of anabolic/androgenic steroids has been shown to produce changes in the body
that may impact an individual immune system. These changes however can be both good and
bad for the user. During steroid treatment for instance, many athletes find they are
less susceptible to viral illnesses. New studies involving the use of compounds like
oxandrolone and Deca-Durabolin with HIV+ patients seem to back up this claim, clearly
showing that these drugs can have a beneficial effect on the immune system. Such
therapies are in fact catching on in recent years, and many doctors are now less reluctant
to prescribe these drugs to their ill patients. But just as a person may be less apt to
notice illness during steroid treatment, the discontinuance of steroids can produce a
rebound effect in which the immune system is less able to fight off pathogens.
This most likely coincides with the rebound activity/production of cortisol, a
catabolic hormone in the body, which may act to suppress immune system functioning.
When the administered steroids are withdrawn, an androgen deficient state is often
endured until the body is able to rebalance hormone production. Since testosterone
and cortisol seem counter each other activity in many ways, the absence of a normal
androgen level may place cortisol in an unusually active state. During this period of
imbalance, cortisol will not only be stripping the body of muscle mass, but it
may also cause the athlete to be more susceptible to colds, flu etc. The proper use
of ancillary drugs [antiestrogens, testosterone stimulating drugs] is the most common
suggestion for helping to avoid this problem, which will hopefully allow the user to
restore a proper balance of hormones once the steroids are removed.
We also cannot ignore the other-hand possibility that steroids could actually increase
cortisol levels in the body during treatment. Termed hypercortisolemia, this effect
is a common occurrence with anabolic/androgenic steroid therapy. This is because
anabolic/androgenic steroids may interfere with the ability for the body to clear
corticosteroids from circulation, due to the fact that in their respective pathways
of metabolism these hormones share certain enzymes. When overloaded with androgens
competing for the same enzymes cortisol may be broken down at a slower rate, and
levels of this hormone will in turn begin build. Due to their strong tendency to
inhibit the activity of the 3beta hydroxysteroid dehydrogenase enzyme, oral c17 alpha
alkylated orals may be particularly troublesome in regards to elevated cortisol levels,
as again this is a common pathway for corticosteroid metabolism. Though an elevated
cortisol level is not a common concern during most typical steroid cycles, problems
can certainly become evident when these drugs are used at very high doses or for
prolonged periods of time. This of course may lead to the athlete becoming "run-down"
and more susceptible to illness, as well as foster a more over-trained and static
[less anabolic] state of metabolism.
Since your kidneys are involved in the filtration and removal of byproducts from the
body, the administration of steroidal compounds [which are largely excreted in the urine]
may cause them some level of strain. Actual kidney damage is most likely to occur when
the steroid user is suffering from severe high blood pressure, as this state can place
an undue amount of stress on these organs. There is actually some evidence to suggest
that steroid use can be linked to the onset of Wilms Tumor in adults, which is a rapidly
growing kidney tumor normally seen in children and infants. Such cases are so rare however,
that no conclusive link has been established. Obviously the kidneys are vital to ones heath,
so the possibility of any kind of damage [although low] should not be ignored during
heavy steroid treatment. If the user is noticing a darkening of color [in some cases a
distinguishable amount of blood], or pain/difficulty when urinating, kidneys strain might
be a legitimate concern. Other warning signs include pain in the lower back
[particularly in the kidney areas], fever and edema [swelling]. If organ damage is feared,
the administered steroidal compounds should be discontinued immediately, and the doctor
paid a visit to rule out any serious trouble. Since kidney stress/damage is generally
associated with the use of stronger aromatizing compounds such as testosterone and
Dianabol [which often raise blood pressure], individuals sensitive to high blood
pressure/kidney stress should such compounds until health concerns are safely avoided.
If steroid use is still necessitated by the individual, it may be a good idea to avoid
the stronger compounds and opt for one of the milder anabolics. Primobolan, Anavar and
Winstrol for example do not convert to estrogen at all, and likewise may be acceptable
options. Also favorable drugs in this regard are Deca-Durabolin and Equipoise, which
have only a low tendency to convert to estrogen.
Liver stress/damage is not a side effect of steroid use in general, but is specifically
associated with the use of c17 alpha alkylated compounds. As mentioned earlier, these
structures contain chemical alterations that enable them to be administered orally.
In surviving a first pass by the liver, these compounds place some level of stress on
the organ. in some instances this has led to severe damage, even fatal liver cancer.
The disease peliosis hepatitis is one worry, which is an often life threatening
condition where the liver develops blood filled cysts. Liver cancer [hepatic carcinoma]
has also been noted in certain cases. While these very serious complications have
occurred on certain occasions where liver-toxic compounds were prescribed for
extended periods, it is important to stress however that this is not very common
with steroid using athletes. Most of the documented cases of liver cancer have in fact
been in clinical situations, particularly with the use of the powerful oral androgen
Anadrol 50 [oxymetholone]. This may be directly related to the high dosage of this
preparation, as Anadrol 50 contains a whopping 50mg of active steroid per tablet.
This is a considerable jump from other oral preparations, most of which contain 5mg
or less of a substance. With one Anadrol 50 tablet, the liver will therefore have
to process [roughly] the equivalent of 10 Dianabol tablets. This obvious stress is
further amplified when we look at the unusually high dosage schedule for ill patients
receiving this medication. With Anadrol 50, the manufacturer recommendations may call
for the use of as many as 8 or 10 tablets daily. This is of course a far greater
amount than most athletes would ever think of consuming, with three or four tablets
per day being considered the upper limit of safety. It is also important to note that
the actual number of cases involving liver damage have been few, and have not been a
significant enough of a problem to warrant discontinuing this compound.
Methyltestosterone, this first steroid shown to cause liver trouble, is also still
available as a prescription drug in this country. The average recreational steroid
user who takes toxic orals at moderate dosages for relatively short periods is therefore
very unlikely to face devastating liver damage.
Although severe liver damage may occur before the onset of noticeable symptoms, it is
most common to notice jaundice during the early stages of such injury. Jaundice is
characterized by the buildup of bilirubin in the body, which in this case will usually
result from the obstruction of bile ducts in the liver. The individual will typically
notice a yellowing of the skin and eye whites as this colored substance builds in the
body tissues, which is a clear sign to terminate the use of any c17 alpha alkylated
steroids. In most instances the immediate withdrawal of these compounds is sufficient
to reverse and prevent any further damage. Of course the athlete should avoid using orals
for an extended period of time, if not indefinitely, should jaundice occur repeatedly
during treatment. It is also a good idea to visit your physician during oral treatment
in order to monitor liver enzyme values. Since liver stress will be reflected in
your enzyme counts well before jaundice is noticed, this can remove much of the worry
with oral steroid treatment.
Prostate cancer is currently one of the most common forms of cancer in males.
Benign prostate enlargement [a swelling of prostate tissues often interfering with
urine flow] can precede/coincide this cancer, and is clearly an important medical concern
for men who are aging. Prostate complications are believed to be primarily dependent
on androgenic hormones, particularly the strong testosterone metabolite DHT in normal
situations, much in the same way estrogen is linked to breast cancer in women. Although
the connection between prostate enlargement/cancer and steroid use is not fully
established, the use of steroids may theoretically aggravate such conditions by raising
the level of androgens in the body. It is therefore a good idea for older athletes to
limit/avoid the intake of strong 5-alpha reducible androgens like testosterone,
methyltestosterone and Halotestin, or otherwise use Proscar [finasteride], which was
specifically designed to inhibit the 5-alpha reductase enzyme in scalp and prostate
tissues. This may be an effective preventative measure for older athletes who insist
on using these compounds. Drugs like Dianabol, Anadrol 50 and Proviron, which do
not convert to DHT yet are still potent androgens, are not effected by its use however.
It is also important to mention that not only androgens but also estrogens are necessary
for the advancement of this condition. It appears that the two work synergistically
to stimulate benign prostatic growth, such that one without the other would not be
enough to cause it. It has therefore been suggested that non-aromatizable compounds
may be better options for older men looking for androgen replacement than lowering
androgenic activity in the prostate. It is easier to accomplish, and should be
accompanied with less side effects. It would also be very sound advice, regardless of
steroid use, for individuals over 40 to have a physician check the prostate on
somewhat of a regular basis.
The functioning of the male reproductive system depends greatly on the level of androgenic
hormones in the body. The use of synthetic male hormones may therefore have a dramatic
impact on an individual sexual wellness. On one extreme we may see a man libido and erection
frequency become extremely heightened. This is most commonly seen with the use of strongly
androgenic steroids, which seem to have the most dramatic stimulating impact on this system.
In some instances this can reach the point of becoming a problem, although more often than
not the athlete is simply much more active and aggressive sexually during the intake of
On the other extreme we may also see a lack of sexual interest, possibly to the point of
impotency. This occurs mainly when androgenic hormones are at a very low. This will often
happen after a steroid cycle is discontinued, as the endogenous production of testosterone
is commonly suppressed during the cycle. Removing the androgen [from an outside source]
leaves the body with little natural testosterone until this imbalance is corrected. The
loss of its metabolite DHT is particularly troubling, as this hormone may have a strong
affect on the reproductive system that may not be apparent with other less androgenic
hormones. It is therefore a very good idea to use testosterone-stimulating drugs like
HCG and/or Clomid/Nolvadex when coming off of a strong cycle, so as to reduce the
impact of steroid withdrawal. Impotency/sexual apathy may also occur during the course
of a steroid cycle, particularly when it is based strictly on anabolic compounds.
Since all "anabolics" can suppress the manufacture of testosterone in the body, the
administered drugs may not be androgenic enough to properly compensate for the
testosterone loss. In such a case the user might opt to include a small androgen dosage
[perhaps a weekly testosterone injection], or again to reverse/prevent the androgen
suppression with the use of medications like Clomid or HCG.
It is also interesting to note that it is not always simply an androgen vs. anabolic issue.
People will often respond very differently to an equal dose of the same drug.
While one individual may notice sexual disinterest or impotency, another may become
extremely aggressive. It is therefore difficult to predict how someone will react to a
particular drug before having used it.
Many anabolic/androgenic steroids have the potential to impact an individual stature if
taken during adolescence. Specifically, steroids can stunt growth by stimulating the
epiphyseal plates in a person long bones to prematurely fuse. Once these plates are fused,
future liner growth is not possible. Even if the individual avoids steroid use
subsequently, the damage is irreversible and he/she can be stuck at the same height
forever. Not even the use of growth hormone can reverse this, as this powerful hormone
can only thicken bones when used during adulthood. Interestingly enough it is not the
steroids themselves, but the buildup of estrogen that causes the epiphyseal plates to fuse.
Women are shorter than men on average because of this effect of estrogen, and likewise
the use of steroids that readily convert to estrogen can prematurely suppress/halt
a person growth. In fact, the use of steroids like Anavar, Winstrol and Primobolan
[which do not convert to estrogen] can actually increase ones height if taken during
adolescence, as their anabolic effects will promote the retention of calcium in the bones.
This would also hold true for non-aromatizing androgens such as trenbolone, Proviron
and Halotestin. It is of course still good common sense to advise adolescents to avoid
steroid use, at least until their bodies are fully mature and steroid use will have a
less dramatic impact.
The human body always prefers to remain in a very balanced hormonal state, a tendency
known as homeostasis. When the administration of androgens from an outside source causes
a surplus of hormone, it will cause the body to stop manufacturing its own testosterone.
Specifically this happens via a feedback mechanism, where the hypothalamus detects a high
level of sex steroids [including androgens, progestins and estrogens] and shuts off the
release of GnRH [Gonadotropin Releasing Hormone, formerly referred to as luteinizing
hormone releasing hormone]. This in turn causes the pituitary to stop releasing
luteinizing hormone and FSH [follicle stimulating hormone], the two hormones
[primarily LH] that stimulate the Leydig cells in the testes to release testosterone
[negative feedback inhibition has been demonstrated at the pituitary level as well].
Without stimulation by LH and FSH the testes will be in a state of production limbo,
and may shrink from inactivity. In extreme cases the steroid user can notice testicles
that are unusually and frighteningly small. This effect is temporary however, and once
the drugs are removed [and hormone levels rebalance] the testicles should return to
their original size. Many regular steroid users find this side effect quite troubling,
and use ancillary drugs like Clomid/Nolvadex or HCG during a steroid cycle in order to
try to maintain testicular activity [and size] during treatment. The more estrogenic
androgens [testosterone, Anadrol 50 and Dianabol] are of course most dramatic in this
regard, and are therefore poor choices for individuals who seriously want to avoid
testicle shrinkage. Non-aromatizing anabolics would be a better option, however be
warned that all steroids should have an impact on the production of testosterone if
taken at an anabolically effective dosage [yes, even Anavar and Primobolan].
Water and Salt Retention
Many anabolic/androgenic steroids can increase the amount of water and sodium stored in
body tissues. In some instances steroid induced water retention can bring about a very
bloated appearance to the body [hands, arms, face etc.], which will also reduce the
visibility of muscle features [loss of definition]. Athletes often ignore this side
effect, particularly during bulking cycles when the excess water stored in the muscles,
joints and connective tissues will help to improve an individual overall strength.
With the use of many strong androgens, water retention can account for much of the
initial strength and body weight gain during steroid treatment, with "water-weight"
sometimes amounting to ten or more pounds. Although water retention may not be the most
unwelcome side effect during a bulking cycle [greater strength and mass], it can lead to
dangerous problems such as high blood pressure and kidney damage. The body is clearly
under more strain when dealing with an unusually high level of water, so athletes should
not simply ignore this. Water retention is most specifically associated with the presence
of estrogen in the body, and is therefore common with the use of aromatizing compounds
[such as testosterone and Dianabol]. If water retention becomes an obvious problem
during a cycle, the use of an antiestrogen [Nolvadex, Proviron] may help minimize it.
The antiaromatase Arimidex is in fact the most effective option, which inhibits the
conversion of testosterone to estrogen. Sometimes the athlete will alternately option
for a diuretic, which can rapidly shed the water so as to achieve a more
comfortable/attractive physique in a very short time. This is a common practice when
preparing for a competition, as diuretic use allows the user a great level of control
over water stores. Of course discontinuing the offending compounds, or substituting
them with a milder anabolic would be the simplest option for recreational steroid users.
Since anabolic/androgenic steroids are synthetic male hormones, they can produce a number
of undesirable changes when introduced into the female body. This includes the
possibility of "virilization", which refers to the tendency for women to develop
masculine characteristics when taking these drugs. Virilization symptoms include a
deepening or hoarseness of the voice, changes in skin texture, acne, menstrual
irregularities, increased libido, hair loss [scalp], body/facial/pubic hair growth and
an enlargement of the clitoris. In extreme cases the female genitalia can become very
disfigured, and may actually take on a penis-like appearance. Women must clearly be
very careful when considering the use of steroids, especially since most virilization
symptoms are irreversible. The stronger androgenic compounds should obviously be
off-limits, with cautious female athletes restricting themselves to the use of only
mild anabolics such as Winstrol, Primobolan, Anavar and Durabolin [the shorter
acting nandrolone]. Nandrolone is actually the preferred hormone, as it displays the
lowest level of androgenic to anabolic activity. Since even these milder anabolics have
the potential to cause problems however, users should additionally remember to be
conservative with drug dosages and duration of intake. After each cycle of course a
notable break from treatment would be a good idea as well, so that the body has
sufficient time to re-establish a hormonal balance.